WebJan 14, 2024 · The pathophysiology of TA-TMA is complex, resulting from a cycle of activation of endothelial cells to produce a procoagulant state, along with activation of antigen-presenting cells and lymphocytes, as well as activation of the complement cascade and microthrombi formation. If not promptly diagnosed and treated, TA-TMA can lead to … WebThrombotic microangiopathy ( TMA) is a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury. [1] It may be seen in association with thrombocytopenia, anemia, purpura and …
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