Relaxin fusion
WebJun 16, 2024 · 1. A heterodimeric fusion comprising: (i) a first heterodimerisation domain connected to at least one Relaxin A chain polypeptide or a variant thereof; and (ii) a second heterodimerisation domain connected to at least one Relaxin B chain polypeptide or a variant thereof, wherein the first heterodimerisation domain heterodimerises with the … WebDisclosed are human relaxin-Fc fusion proteins having an increased serum half-life, polynucleotides encoding the same, and intermediates formed during the fusion protein biosynthesis. The fusion proteins may include a linker portion or other sections as well. Suitable fusion proteins are also those predicted to have the same effect as human …
Relaxin fusion
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WebThe present invention provides Relaxin fusion polypeptides A-L-B with a non-wild type array of the Relaxin A-chain and Relaxin B-chain, wherein the A-and B-chains are connected by a linker peptide. The invention further provides Relaxin fusion polypeptides with extended half-life. Furthermore, the invention provides nucleic acid sequences encoding the … WebRelaxin. Relaxin is a reproductive hormone produced by your ovaries and the placenta. It loosens and relaxes your muscles, joints and ligaments during pregnancy to help your …
WebDec 17, 2024 · In vitro activity in relaxin/insulin-like family peptide receptor 1 (RXFP1) CHO and THP-1 cells. The in vitro activity of relaxin-2 and RELAX10 (a fusion protein … WebSUMMARY The present invention relates to Relaxin heterodimeric fusion polypeptides, in particular, to Relaxin 2 heterodimeric fusion polypeptides and uses thereof. Thus, the …
WebJan 25, 2002 · Abstract. Relaxin is a hormone important for the growth and remodeling of reproductive and other tissues during pregnancy. Although binding sites for relaxin are widely distributed, the nature of its receptor has been elusive. Here, we demonstrate that two orphan heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors ... WebDec 12, 2003 · The PCR product was cloned into the modified pCMV-sport1 between EcoRI and BamHI sites and the insert region was sequenced to confirm the sequence identity. The construct encodes a secreted relax-in-3 fusion peptide with a FLAG tag at the N terminus. The FLAG-relaxin-3 fusion peptide expressing plasmid was transfected into COS-7 cells.
WebDec 17, 2024 · Methods and Results We developed RELAX10, a fusion protein composed of human relaxin-2 hormone and the Fc of a human antibody, to test the hypothesis that …
WebDec 10, 2024 · The relaxin‐2 peptide was cloned as a C‐terminal fusion to wild‐type Fc, then expressed in CHO G22 cells and purified as described in Materials and Methods. Analysis of the purified protein via mass spectrometry confirmed the purified protein (RELAX10) has the expected mass under reduced and nonreduced conditions (data not shown). citing multiple authors in text citationWebNov 4, 2024 · Released relaxin fusion protein Protein chain Vesicle Golgi. Slide 5 Moderna’srelaxin program (mRNA-0184) is being developed to treat decompensated heart … citing multiple authors in text mlaWebThe human relaxin-2 gene, RLN2, location 9p24.1, consists of two exons (E-Figure 19E.6).The relaxin-1 gene arose as a result of an ancestral duplication of the relaxin-2 gene [5].All RLN family genes evolved from a relaxin-3 like ancestral gene (Figure 19E.2) [2].RLN family peptides are synthesized as preprohormones composed of a signal sequence and … diatta shirt numberWebJan 28, 2024 · Materials and Methods Homology Modelling of the Putative Relaxin Family Peptide Receptor 1 Structure. The human RXFP1 is constituted by 757 amino acids, with half assigned to the N-terminal extracellular part (Kong et al., 2010).A homology model of the RXFP1 was created to predict and visualize putative structural properties and more … diatribe websiteWebHuman Relaxin-2, also called H2 Relaxin, is a 6 kDa, 53 amino acid (aa) nonglycosylated, heterodimeric polypeptide that plays an important role in female reproduction (1, 2). … citing multiple authors mla et aldia tsa precheck hoursWebOct 23, 2002 · Claims 15 to 17 related to processes for making a DNA transfer vector comprising relaxin DNA, for making a fusion protein comprising relaxin, and for synthesizing H2-relaxin, respectively. Claims 18 to 24 were directed to H2-relaxin in various forms or to polypeptides having relaxin activity. II. diatrypaceous