Web27 nov. 2015 · The compact state rearranges into a native-like structure immediately after the full domain sequence has emerged from the ribosome. Both folding transitions are … Web5 mrt. 2010 · Such slow refolding from kinetic traps has frequently been observed in studies of other large RNAs (18 ... Changchien LM, Noller HF. RNA–protein interactions in 30S ribosomal subunits: Folding and function of 16S rRNA. Science. 1989; 244:783–790. [Google Scholar] 31. Cruz JA, Westhof E. The dynamic landscapes of RNA ...
Assembly factors chaperone ribosomal RNA folding by isolating
Web29 okt. 2010 · Such kinetic traps are likely avoided in vivo by the participation of assembly cofactors ... Concurrent nucleation of 16S folding and induced fit in 30S ribosome … Recent studies (Addabbo et al., submitted) found that, immediately after translation termination, newly synthesized proteins kinetically partition between the fully folded native state and aggregated conformations. The basic aspects of this process are schematically illustrated in Fig. 5. This partitioning is … Meer weergeven Understanding how proteins achieve their three-dimensional structure (i.e. how they fold) is one of the most compelling problems in … Meer weergeven Large-scale aggregation of proteins—whose biological function requires monomers or monodisperse lower-order supramolecular assemblies—is often undesirable (Amani and Naeem, … Meer weergeven Although most proteins are known to follow Anfinsen’s thermodynamic hypothesis, there are a few that fold under kinetic control (Baker and Agard, 1994; Eder and … Meer weergeven Kinetic trapping under physiological conditions is not a unique characteristic of protein folding and aggregation. For instance, unimolecular kinetic trapping in RNA folding is … Meer weergeven grounds magazine
Beyond kinetic traps in RNA folding - ScienceDirect
Web7 jan. 2024 · Protein Biophysics Folding Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic traps DOI: Authors: Amir Bitran William M. Jacobs Xiadi Zhai Eugene... Web1 jun. 1999 · Large ribozymes fold on a ‘glacials timescale compared to the folding of their protein counterparts. The sluggish folding exhibited by large RNAs results from the … Web3 apr. 2024 · We trap the protein in the nanopore as a rotaxane-like complex using streptavidin stoppers. The protein is subjected to cycles of unfolding-translocation … film action anak