Cisplatin lung toxicity

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August undefined, 2024

WebFeb 22, 2016 · In patients treated for disseminated testicular cancer with bleomycin, etoposide, and cisplatin (BEP), the risk of acute bleomycin-induced changes is ≤ 6.8%, with a 0% to 1% risk of death. 1 - 4 Serious long-term toxicity has been indicated with an increased risk of late mortality caused by pulmonary diseases. 5 These findings were … WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus …

Cisplatin Side Effects: Common, Severe, Long Term

WebTolerability and toxicity of adjuvant cisplatin and gemcitabine for treating non-small cell lung cancer Cisplatin and gemcitabine are feasible for use in the adjuvant setting with a favorable toxicity profile and superior tolerability compared with published data on cisplatin and vinorelbine. WebJun 1, 2016 · The carboplatin-docetaxel arm had a more favourable toxicity profile and a significant number of patients withdrew from the cisplatin-docetaxel doublet due to grade 3–4 emesis ( Greco et al., 2000 ). Other studies have observed the efficacy and tolerability of platinum-gemcitabine regimens in CUP. incandescent light bulb parts

Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and ...

WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ... WebCisplatin, first (platinum) compound to be evolved as an anticancer agent, has found its important place in cancer chemotherapy. However, the dose-dependent toxicities of cisplatin, namely... WebSep 4, 2013 · Short hydration is safe and reduces the frequency of severe renal toxicities in regimens containing cisplatin (≥75 mg/m 2) for the treatment of patients with lung cancer. Cisplatin labels with regard to hydration should accept short- and lower-volume hydration as an option based on the result of the present study. Funding including conjunction

Short Hydration in Chemotherapy Containing Cisplatin (≥75 mg/m

Cisplatin - an overview ScienceDirect Topics

WebThus, the SNP rs10505477 in CASC8 may serve as an underlying risk marker for detecting and diagnosing lung cancer, and could be used to determine the response and toxicity of platinum-based chemotherapy in lung cancer patients. However, further larger well-designed studies will be needed to clarify the biological and clinical significance of ... WebJan 23, 2024 · The major toxicities occur in the lung and skin, where the drug is concentrated. Up to 20% of patients treated with bleomycin develop clinical pulmonary … including comprisingWebAdverse effects of RT-CT were grades 3 to 4 neutropenia (four patients) and grade 3 esophageal toxicity (one patient). No treatment-related deaths occurred. Conclusion: The oral vinorelbine-cisplatin combination with concurrent RT is feasible and has a favorable risk-benefit ratio in stage IIIA/IIIB NSCLC. Publication types including colleges

"WebPulmonary toxicity: Bleomycin can be associated with the development of life-threatening pulmonary toxicity. Maximum lifetime bleomycin dose should not exceed 400 mg. … " - Cisplatin lung toxicity

Cisplatin lung toxicity

Pulmonary Function in Patients With Germ Cell Cancer Treated …

WebDec 7, 2024 · The EC regimen was associated with a higher risk of grade 1–2 haematological toxicities, including anaemia, thrombocytopaenia, hypothyroidism, dyspnoea, infection, hypertension and arrythmia (all p < 0.001), hyponatremia ( p = 0.022) and pneumonia ( p = 0.013), whereas patients who underwent the EP regimen were more …

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WebThe combination of both TAS and its monomers with cisplatin can reduce toxicity and increase effectiveness, which reveals the new role of TAS as a potential anticancer drug in NSCLC treatment. ... Stephania tetrandra and ginseng-containing chinese herbal formulation NSENL reverses cisplatin resistance in lung cancer xenografts. Am. J. Chin. Med ... WebOct 7, 2024 · Cisplatin is one of the most widely prescribed chemotherapeutic drugs, used to treat a wide range of pediatric and adult malignances such as ovarian, testicular, bladder, head, neck, breast and lung [2,3]. It is prescribed …

WebThis suggests that cisplatin-induced lung damage can damage the cilia, manifesting as increased ciliary proteins in the BALF. By increasing oxidative stress in the lung, … Webcancer with Cisplatin is 95% with a 25 year risk of cardiovascular toxicity in 16% patients due to direct endothelial damage of Cisplatin or indirectly induced hormonal and …

WebDec 7, 2024 · In the present study, the carboplatin-containing regimen was associated with a higher incidence of thyroid and pulmonary toxicity. Therefore, for patients with co … WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation.

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WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting. including constraintsWebFeb 22, 2024 · Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung … including containingWebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and monitor renal function and electrolytes. Consider dose reduction or alternative treatments in patients with renal impairment. PERIPHERAL NEUROPATHY: including containing 違いWebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Targeted … including communicationWebMay 9, 2024 · This topic review will provide an overview of the incidence and specific patterns of lung toxicity seen with cytotoxic chemotherapy agents. Separate … including compilerWebMar 22, 2024 · Pulmonary toxicities occur in 10% of treated patients. In approximately 1%, the nonspecific pneumonitis induced by Bleomycin progresses to pulmonary fibrosis and death. Although this is age and … incandescent light bulb signWebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. Hepatotoxicity The platinum compounds generally are not considered to be hepatotoxic, but cisplatin has been associated with a low rate of serum enzyme elevations during therapy. incandescent light bulb swan